绒毛膜癌细胞系的细胞遗传学分析。

Cytogenetic analysis of choriocarcinoma cell lines.

作者信息

Sasaki S, Katayama P K, Roesler M, Pattillo R A, Mattingly R F, Ohkawa K

出版信息

Nihon Sanka Fujinka Gakkai Zasshi. 1982 Dec;34(12):2253-6.

Abstract

Five permanent cell lines were established in vitro from patients with gestational choriocarcinoma. Chromosome study with Q-band technique showed a modal chromosome number per cell in the hypotetraploid range in all cell lines. There were unidentifiable, structurally altered chromosomes in each cell line. BeWo cell line from choriocarcinoma following delivery of a normal male baby lost identifiable Y chromosome, whereas Jar cell line following delivery of a normal male did have a Y chromosome. One of the two cell lines following complete hydatidiform mole had a Y chromosome. The significance of this finding is discussed.

摘要

从妊娠性绒毛膜癌患者中建立了5个永久性体外细胞系。采用Q带技术进行染色体研究显示，所有细胞系中每个细胞的众数染色体数处于亚四倍体范围内。每个细胞系中都存在无法识别的、结构改变的染色体。正常男婴出生后从绒毛膜癌中获取的BeWo细胞系丢失了可识别的Y染色体，而正常男婴出生后获取的Jar细胞系确实有一条Y染色体。完全性葡萄胎后的两个细胞系中有一个有Y染色体。讨论了这一发现的意义。