Hollinger T G, Alvarez I M
J Exp Zool. 1982 Dec 30;224(3):461-4. doi: 10.1002/jez.1402240321.
Xenopus oocytes were exposed to trifluoperazine, a drug that binds to the calcium-regulating protein, calmodulin. The drug induced meiotic maturation even in the absence of progesterone. When trifluoperazine was microinjected directly into oocytes the maturation of the cells was partially inhibited in that the white spot, indicative of germinal vesicle breakdown, did not appear even though the germinal itself was absent in dissected oocytes.
非洲爪蟾卵母细胞被暴露于三氟拉嗪，一种能与钙调节蛋白钙调蛋白结合的药物。即使在没有孕酮的情况下，这种药物也能诱导减数分裂成熟。当将三氟拉嗪直接显微注射到卵母细胞中时，细胞的成熟受到部分抑制，即尽管在解剖的卵母细胞中没有生发泡，但指示生发泡破裂的白斑并未出现。
