Wasserman W J, Masui Y
J Exp Zool. 1975 Sep;193(3):369-75. doi: 10.1002/jez.1401930313.
Meiotic maturation was induced in Xenopus laevis oocytes when the external Ca++ or Mg++ ion concentration was raised above 5 mM in the presence of the ionophore. Ionophore-divalent cation-induced maturation appears to be due to the stimulation of the oocyte itself. Cytoplasm of responding oocytes induced maturation when microinjected into ovarian oocytes. Cycloheximid, an inhibitor of progesterone-induced maturation, inhibited the maturational response induced by the ionophore and divalent cations. Ethidium bromide, an inhibitor of the follicular response to human chorionic gonadotropin, had no effect. The possible roles that Ca++ and Mg++ may play in the initiation of maturation are discussed.
当在离子载体存在的情况下将外部钙离子或镁离子浓度提高到5 mM以上时，非洲爪蟾卵母细胞会诱导减数分裂成熟。离子载体 - 二价阳离子诱导的成熟似乎是由于卵母细胞自身受到刺激。将有反应的卵母细胞的细胞质显微注射到卵巢卵母细胞中时，会诱导成熟。环己酰亚胺是孕酮诱导成熟的抑制剂，它抑制了离子载体和二价阳离子诱导的成熟反应。溴化乙锭是卵泡对人绒毛膜促性腺激素反应的抑制剂，没有作用。文中讨论了钙离子和镁离子在成熟起始过程中可能发挥的作用。
