某些药物和肽类激素对兔离体胆囊对胆囊收缩素反应性的影响。
Effects of some drugs and peptide hormones on the responsiveness of the rabbit isolated gall-bladder to cholecystokinin.
作者信息
Johnson A G, Marshall C E, Wilson I A
出版信息
J Physiol. 1982 Nov;332:415-25. doi: 10.1113/jphysiol.1982.sp014421.
Abstract
- The efficacies of some standard preparations of CCK were compared and the effects of some drugs and peptide hormones on the responsiveness of the rabbit isolated gall-bladder to cholecystokinin were studied with an established automatic method of estimating cholecystokinin. 2. Atropine, propranolol, phentolamine mesylate and lignocaine were shown to have no effect on the responsiveness of the rabbit isolated gall-bladder. 3. Glucagon, somatostatin, pentagastrin, pancreatic polypeptide, motilin and the Karolinska preparation of secretin had no effect on the preparation alone and caused only slight changes when given with cholecystokinin. 4. The Boots preparation of secretin exhibited a small cholecystokinin effect when given alone, but considerably inhibited cholecystokinin-induced contractions. 5. The desulphated C-terminal octapeptide of cholecystokinin also exhibited inhibitory effects.
摘要
- 比较了一些标准缩胆囊素制剂的功效，并采用一种既定的自动测定缩胆囊素的方法，研究了某些药物和肽类激素对家兔离体胆囊对缩胆囊素反应性的影响。2. 结果表明，阿托品、普萘洛尔、甲磺酸酚妥拉明和利多卡因对家兔离体胆囊的反应性无影响。3. 胰高血糖素、生长抑素、五肽胃泌素、胰多肽、胃动素以及卡罗林斯卡研究所制备的促胰液素单独作用于该制剂时无影响，与缩胆囊素合用时仅引起轻微变化。4. 布茨公司制备的促胰液素单独使用时表现出较小的缩胆囊素样作用，但能显著抑制缩胆囊素诱导的收缩。5. 缩胆囊素的去硫酸化C末端八肽也表现出抑制作用。
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