急性氨苯砜中毒后迟发性硫血红蛋白血症。

Delayed sulfhemoglobinemia after acute dapsone intoxication.

作者信息

Lambert M, Sonnet J, Mahieu P, Hassoun A

出版信息

J Toxicol Clin Toxicol. 1982 Mar;19(1):45-50. doi: 10.3109/15563658208990365.

DOI:10.3109/15563658208990365

Abstract

A case of acute Dapsone intoxication due to voluntary ingestion of 3 g of this drug as a suicide attempt is described. A severe methemoglobinemia developed, accompanied by intense cyanosis, dyspnea, headache, and nausea. Subsequently, significant sulfhemoglobinemia responsible for prolonged cyanosis was observed, as well as mild hemolytic anemia. Relapses of methemoglobinemia after methylene blue treatment required repeated administration of the reducing agent. The need of a careful follow-up for several days in this type of intoxication is emphasized.

摘要

本文描述了一例因自杀企图自愿摄入3克氨苯砜导致急性氨苯砜中毒的病例。患者出现了严重的高铁血红蛋白血症，伴有严重的发绀、呼吸困难、头痛和恶心。随后，观察到导致长期发绀的显著硫血红蛋白血症，以及轻度溶血性贫血。亚甲蓝治疗后高铁血红蛋白血症复发，需要反复给予还原剂。强调了对这类中毒患者进行数天仔细随访的必要性。