Mattiasson A, Uvelius B
J Urol. 1982 Dec;128(6):1340-2. doi: 10.1016/s0022-5347(17)53503-x.
Hypertrophy was induced in female rat urinary bladders by partial obstruction of the urethra. After 6 weeks the bladder weight had increased almost 7-fold compared to the matched controls. At this stage the animals were anesthetized and the pelvic nerves stimulated bilaterally at different bladder volumes. Isovolumetric pressures were measured by means of a catheter inserted via the urethra. For control (C) bladders maximum active pressure (104 +/- 11 cm. H2O, n = 5) was attained with 0.10 ml. content. For volumes above this a rapid progressive decrease in active pressure was noted. For hypertrophic (H) bladders maximum active pressure (92 +/- 14 cm. H2O, n = 6) was reached at 0.50 ml. Further filling decreased active pressure only slightly. By use of the law of Laplace the volume-active pressure relations were transformed to radius-force curves. The maximum active stress was similar for C and H bladders. The radius-force relation for H bladders was shifted to the right compared to the C curve (optimum radius for active force: C: 0.4 cm., H: greater than 0.9 cm.). This shift, responsible for the decreased ability to pressure production of the H bladders at small volumes indicates a dramatic remodelling of the smooth muscle in the hypertrophic bladder wall.
通过部分尿道梗阻诱导雌性大鼠膀胱肥大。6周后，与配对对照组相比，膀胱重量增加了近7倍。在此阶段，将动物麻醉，并在不同膀胱容量下双侧刺激盆腔神经。通过经尿道插入的导管测量等容压力。对于对照（C）膀胱，0.10 ml容量时达到最大主动压力（104±11 cm H₂O，n = 5）。对于高于此容量的情况，主动压力迅速逐渐下降。对于肥大（H）膀胱，0.50 ml时达到最大主动压力（92±14 cm H₂O，n = 6）。进一步充盈仅使主动压力略有下降。利用拉普拉斯定律将容量-主动压力关系转换为半径-力曲线。C组和H组膀胱的最大主动应力相似。与C组曲线相比，H组膀胱的半径-力关系向右移动（产生主动力的最佳半径：C组：0.4 cm，H组：大于0.9 cm）。这种移动导致H组膀胱在小容量时产生压力的能力下降，表明肥大膀胱壁中的平滑肌发生了显著重塑。
