Akutsu S, Katoh M, Kawana K, Shimamura T, Fukushima Y, Matsuzaki M
Jpn J Antibiot. 1982 Aug;35(8):2100-10.
Fertility study on amikacin sulfate (AMK) was carried out in Wistar rats. AMK was administered intraperitoneally at the doses of 0, 25, 100 mg/kg/day and 200 mg/kg/day in males for 60 days prior to mating and mating period and in females for 14 days prior to mating, mating period and day 0-7 of gestation. The drug induced no significant changes or signs in parent animals, except that soft feces was occasionally found at the 100 mg/kg/day and 200 mg/kg/day and the impairment in kidneys was recognized only at the 200 mg/kg/day. There were no adverse effects on mating, fertility or reproduction indices in males and females. And there were no evidences of teratogenic or embryotoxic effects in at any doses of AMK.
对硫酸阿米卡星（AMK）进行了生育力研究，使用的是Wistar大鼠。雄性大鼠在交配前60天以及交配期间，雌性大鼠在交配前14天、交配期间以及妊娠第0至7天，分别以0、25、100mg/kg/天和200mg/kg/天的剂量腹腔注射AMK。除了在100mg/kg/天和200mg/kg/天剂量组偶尔发现软便，以及仅在200mg/kg/天剂量组发现肾脏损伤外，该药物未引起亲代动物出现显著变化或体征。对雄性和雌性动物的交配、生育力或繁殖指标均无不良影响。并且在任何剂量的AMK下均未发现致畸或胚胎毒性作用的证据。
