Gachon P, Moins N, Maublant J
J Pharmacol Methods. 1982 Nov;8(3):213-23. doi: 10.1016/0160-5402(82)90075-4.
A new method for rapid and noninvasive assessment of vasoactive drugs is described, using scintigraphic imaging with thallium-201 in anesthetized dogs. The scintigraphic images were processed to evaluate the effects of the vasoactive agents studied upon the biodistribution of thallium-201 in the whole body of dogs. The calculation of the functional parameter was based upon the comparison of the cell by cell increase of the tracor uptake following two different injections: the first in the basal state, the second after treatment with a vasoactive drug. Six drugs were tested and their effects evaluated in heart, liver, lungs, kidneys, and skeletal muscles. The most marked effects on myocardium were observed with dipyridamole and the ionophore grisorixin, two coronary vasodilators, which induced a strong increase in the TI-201 myocardial uptake (168.9 +/- 31.6% and 194.9 +/- 34.2% respectively). The results obtained in the other organs with all the drugs tested were in accord with their known hemodynamic properties, and so confirm the usefulness of this method.
本文描述了一种在麻醉犬中使用铊-201闪烁成像对血管活性药物进行快速、无创评估的新方法。对闪烁图像进行处理，以评估所研究的血管活性药物对铊-201在犬全身生物分布的影响。功能参数的计算基于两次不同注射后示踪剂摄取逐细胞增加的比较：第一次在基础状态下注射，第二次在用血管活性药物治疗后注射。测试了六种药物，并评估了它们在心脏、肝脏、肺、肾脏和骨骼肌中的作用。两种冠状动脉扩张剂双嘧达莫和离子载体灰霉素对心肌的影响最为显著，它们使TI-201心肌摄取显著增加（分别为168.9±31.6%和194.9±34.2%）。在其他器官中，所有测试药物获得的结果均与其已知的血流动力学特性相符，从而证实了该方法的实用性。
