Maublant J, Moins N, Gachon P
J Nucl Med. 1981 Oct;22(10):921-4.
The effect of drugs on thallium-201 biodistribution in the body has been studied in dogs using a new functional imaging method. The calculation is based upon the comparison of the activities of the two scintigraphic images obtained after two successive injections of thallium-201 separated by an interval of at least 10 min, during which some drug of interest can be administered. This imaging technique was applied in control dogs (n = 6) and in animals treated with dipyridamole (n = 7) or grisorixin (n = 7). As expected, these two vasoactive drugs increased mainly the myocardial uptake, whereas smaller variations were noted in the other organs studied: liver, kidney, lungs, and skeletal muscles. Thus this method should allow a rapid and reliable noninvasive assessment of cardiovascular drugs with thallium-201.
利用一种新的功能成像方法，在犬类动物身上研究了药物对铊-201在体内生物分布的影响。该计算基于对两次连续注射铊-201（间隔至少10分钟）后获得的两张闪烁扫描图像的活性进行比较，在此期间可给予某种感兴趣的药物。这种成像技术应用于对照犬（n = 6）以及接受双嘧达莫治疗的动物（n = 7）或灰黄霉素治疗的动物（n = 7）。正如预期的那样，这两种血管活性药物主要增加了心肌摄取，而在所研究的其他器官（肝脏、肾脏、肺和骨骼肌）中观察到的变化较小。因此，这种方法应该能够对使用铊-201的心血管药物进行快速且可靠的非侵入性评估。
