Hancock R L
Med Hypotheses. 1982 Oct;9(4):421-7. doi: 10.1016/0306-9877(82)90082-2.
By the use of a simplistic concept of the structure of heterochromatin, one can derive a formulation for the mechanism by which the phenomenon of V-type position effect can repress genic activity. This notion would explain how the Bar locus and other position effect examples cause genic repression. The mechanism, when extended, may also explain the process of cancer induction by hereditary means. In its most concise form the theory states that heterochromatin has a stabilized structure through special proteins, such as phosphorylated species that allows it the capacity to induce new domains of a "pseudo-heterochromatic" conformation to juxta-positional euchromatic segments for short distances by virtue of electrostatic and hydrogen bond forces.
通过使用异染色质结构的一个简单概念，人们可以推导出一个关于V型位置效应现象抑制基因活性机制的公式。这一概念将解释棒眼基因座和其他位置效应实例如何导致基因抑制。当扩展该机制时，它或许还能解释遗传性癌症诱发过程。该理论最简洁的形式表述为，异染色质通过特殊蛋白质（如磷酸化种类）具有稳定的结构，这使其能够借助静电和氢键力，在短距离内将“假异染色质”构象的新结构域诱导至相邻的常染色质片段。
