Bacou F
Reprod Nutr Dev (1980). 1982;22(1B):227-33. doi: 10.1051/rnd:19820209.
Acetylcholinesterase in the muscles of birds and mammals has several molecular forms with the same catalytic activity; these forms can be distinguished by their macromolecular properties. The presence of such asymmetric forms as A12 (triple tetramer with a collagen-like tail) is related to motor nerve functioning. Although, contrary to rat, they are always detected in nerve-free samples of chicken muscle, these asymmetric forms disappeared after various muscles of adult chicken and rabbit were denervated in our experiments. They appear in bird embryos at the time when the neuromuscular contacts are formed. The existence of asymmetric forms may depend on the contractile activity of muscle fibers and thus on the functioning of motor innervation. They could be good indicators of neuromuscular interactions.
鸟类和哺乳动物肌肉中的乙酰胆碱酯酶有几种具有相同催化活性的分子形式；这些形式可通过其大分子特性加以区分。诸如A12（具有类胶原尾巴的三聚体四聚体）等不对称形式的存在与运动神经功能有关。虽然与大鼠不同，在鸡肌肉的无神经样本中总能检测到这些不对称形式，但在我们的实验中，成年鸡和兔的各种肌肉去神经支配后，这些不对称形式消失了。它们在鸟类胚胎中神经肌肉接触形成时出现。不对称形式的存在可能取决于肌纤维的收缩活动，进而取决于运动神经支配的功能。它们可能是神经肌肉相互作用的良好指标。
