Shaw R A, Jones R S
Surgery. 1978 Nov;84(5):622-5.
Mongrel dogs were prepared by cholecystectomy, ligation of the lesser pancreatic duct, and insertion of gastric and duodenal cannulas. The common bile duct was cannulated through the duodenal fistula for bile collection while the enterohepatic circulation of bile salts was maintained by intravenous infusion of sodium taurocholate. Cholecystokinin (CCK) and cholecystokinin octapeptide (CCK-OP) caused increased bile flow and had no influence on the biliary clearance of erythritol. The results indicate that the predominant mechanism of CCK and CCK-OP choleresis is due to ductular stimulation.
选用杂种犬，行胆囊切除术、结扎胰小导管，并插入胃和十二指肠插管。通过十二指肠瘘管将胆总管插管以收集胆汁，同时通过静脉输注牛磺胆酸钠维持胆盐的肠肝循环。胆囊收缩素（CCK）和八肽胆囊收缩素（CCK-OP）可使胆汁流量增加，对赤藓醇的胆汁清除率无影响。结果表明，CCK和CCK-OP引起胆汁分泌的主要机制是由于小胆管受到刺激。
