Barontini F, Catarzi L, Lambruschini P
Riv Patol Nerv Ment. 1982 Sep-Oct;102(5):227-38.
This paper deals with two cases of carcinomatous meningitis as metastatic reproduction respectively of a bronchial and a stomach carcinoma. In both patients (37 and 62 years) the clinical picture consisted in combined neurologic symptoms and signs of brain and spinal roots damage, while in the first one there was also a deficit of some cranial nerves. In the past history of the subjects there had been no evidence of tumours. The diagnosis remained uncertain for a long period, although several laboratory and neuroradiologic investigations had been carried out. The C.S.F. cytomorphologic study, performed with the filtration method, gave a rapid and exact identification of carcinomatous cells and, therefore, a correct diagnosis. Such C.S.F. diagnostic test should be carried out in all cases of suspected carcinomatous meningitis. If biochemical markers are used as well, this combination of tests gives additional information.
本文探讨了两例癌性脑膜炎病例，分别为支气管癌和胃癌的转移复发。两名患者（年龄分别为37岁和62岁）的临床表现均为脑和脊神经根损伤的神经症状和体征合并出现，而首例患者还存在一些颅神经功能缺损。在这些患者的既往病史中，均无肿瘤证据。尽管进行了多项实验室和神经放射学检查，但长期以来诊断仍不明确。采用过滤法进行的脑脊液细胞形态学研究能够快速准确地识别癌细胞，从而做出正确诊断。对于所有疑似癌性脑膜炎的病例，均应进行此类脑脊液诊断检测。若同时使用生化标志物，这种检测组合可提供更多信息。
