Valtonen M H, Uusi-Rauva A, Eriksson L
Scand J Clin Lab Invest. 1982 Oct;42(6):507-12.
Reliability of plasma creatinine and urea concentrations and clearances in evaluation of renal function was studied in four goats on two diets of equal energy content but differing in protein (14% and 2% of dry matter). Glomerular filtration rate (GFR) was measured with [hydroxymethyl-14C] inulin. GFR was 88.6 +/- 8.4 ml/min on the high protein diet and 36.9 +/- 2.9 ml/min on the low protein diet. The endogenous creatinine clearance values agreed with the inulin clearances on both diets. Reduction of protein intake was followed by significant increase in plasma creatinine concentration (from 83.8 +/- 3.6 mumol/l during high protein diet to 124.6 +/- 3.5 mumol/l during low protein diet). Plasma urea concentration, urea clearance and urea excretion fell to a very low level during low protein intake. Endogenous creatinine clearance seems to be suitable for measurement of GFR even during protein deprivation when GFR is decreased.
在四只山羊身上研究了血浆肌酐和尿素浓度及清除率在评估肾功能方面的可靠性，这四只山羊食用两种能量含量相等但蛋白质含量不同（分别为干物质的14%和2%）的日粮。用[羟甲基 - 14C]菊粉测量肾小球滤过率（GFR）。高蛋白日粮时GFR为88.6±8.4毫升/分钟，低蛋白日粮时为36.9±2.9毫升/分钟。两种日粮下内源性肌酐清除率值与菊粉清除率一致。蛋白质摄入量减少后，血浆肌酐浓度显著升高（从高蛋白日粮时的83.8±3.6微摩尔/升升至低蛋白日粮时的124.6±3.5微摩尔/升）。低蛋白摄入期间，血浆尿素浓度、尿素清除率和尿素排泄降至非常低的水平。即使在蛋白质缺乏且GFR降低时，内源性肌酐清除率似乎也适用于测量GFR。
