Brouhard B H, Travis L B, Cunningham R J, Berger M, Carvajal H F
Pediatrics. 1977 Feb;59(2):219-23.
Glomerular filtration rate (GFR) is often used to evaluate and manage patients with renal disease. Few studies in children have compared accurate estimations of GFR (clearance of inulin and/or iothalamate) with the clearance of creatinine which, because of simplicity, has been used as an approximation of GFR. At reduced levels of GFR, studies in adults suggest that the mean of the creatinine and urea clearances closely approximate the GFR. The present investigation shows that the clearance of creatinine approximates the GFR at normal levels; however, at reduced levels the creatinine clearance and the mean of the creatinine and urea clearances both overestimate the GFR as measured by iothalamate. The clearance of creatinine remains a useful clinical tool if its limitations at low levels of GFR are realized.
肾小球滤过率（GFR）常用于评估和管理肾病患者。儿童中很少有研究将GFR的准确估计值（菊粉和/或碘他拉酸盐清除率）与肌酐清除率进行比较，由于操作简便，肌酐清除率已被用作GFR的近似值。在成人中进行的研究表明，在GFR降低水平时，肌酐和尿素清除率的平均值与GFR非常接近。本研究表明，在正常水平时肌酐清除率与GFR接近；然而，在降低水平时，肌酐清除率以及肌酐和尿素清除率的平均值均高于通过碘他拉酸盐测量的GFR。如果认识到肌酐清除率在低GFR水平时的局限性，它仍然是一种有用的临床工具。
