Madsen T, Wallin L, Boesby S, Larsen V H
Scand J Gastroenterol. 1982 Sep;17(6):811-5. doi: 10.3109/00365528209181098.
Prolonged measurements of pH and peristalsis in the oesophagus do not enable quantitation of the reflux material. Eight healthy subjects underwent 12-h continuous pH and pressure recording in the oesophagus and, subsequently, recording of pH and spontaneous peristaltic activity after instillation of 0.1 N HCl. Volumes of 2.5, 5, 10, and 15 ml were instilled in the lower end of the oesophagus in randomized order. No relationship between volume and peristaltic activity could be demonstrated. A direct relationship between the change in pH after instillation and the peristaltic activity was demonstrated (r = 0.8052; p less than 0.001). The clearing efficiency was 0.3 pH units per peristaltic contraction. A similar relationship could be found between the change of pH during a spontaneous reflux episode and the following peristaltic activity (r = 0.5993; p less than 0.002). The clearing efficiency was 0.37 pH units per peristaltic contraction. It is concluded that low pH is the determining factor for eliciting oesophageal peristalsis.
对食管pH值和蠕动进行长时间测量无法对反流物质进行定量分析。8名健康受试者在食管中进行了12小时的连续pH值和压力记录，随后，在滴注0.1N盐酸后记录pH值和自发蠕动活动。分别以随机顺序向食管下端滴注2.5、5、10和15毫升的盐酸。未发现滴注量与蠕动活动之间存在关联。滴注后pH值变化与蠕动活动之间存在直接关联（r = 0.8052；p < 0.001）。每次蠕动收缩的清除效率为0.3个pH单位。在自发反流发作期间的pH值变化与随后的蠕动活动之间也发现了类似的关系（r = 0.5993；p < 0.002）。每次蠕动收缩的清除效率为0.37个pH单位。研究得出结论，低pH值是引发食管蠕动的决定性因素。
