Keen C L, Mark-Savage P, Lönnerdal B, Hurley L S
Teratology. 1982 Oct;26(2):163-5. doi: 10.1002/tera.1420260208.
The teratogenicity of D-penicillamine was studied using the Sprague-Dawley rat. Fetuses from rats fed diets containing 0.83% D-penicillamine during pregnancy had a high incidence of malformations. Maternal and fetal tissue copper levels were significantly lower in the D-penicillamine group than in controls, suggesting that the teratogenicity of the drug may be due in part to the induction of copper deficiency by its chelating properties.
使用斯普拉格-道利大鼠研究了D-青霉胺的致畸性。孕期食用含0.83% D-青霉胺饮食的大鼠所产胎儿出现畸形的发生率很高。D-青霉胺组母体和胎儿组织中的铜水平显著低于对照组，这表明该药物的致畸性可能部分归因于其螯合特性导致的铜缺乏。
