Wenzel D G, Hale T W
Toxicology. 1978 Oct;11(2):109-17. doi: 10.1016/s0300-483x(78)90789-8.
Capric (C10:0), lauric (C12:0), myristic (C14:0), palmitic (C16:0), stearic (C18:0) and arachidic (C20:0) acids were compared for their toxic effects upon cultured rat heart muscle and endothelioid cells. The free fatty acids (FFA) were found to albumin (6:1) and tested at 5 x 10(-5)M. Reduction of cell viability (51Cr release) and in situ mitochondrial and lysosomal labilization were used as indices of injury. Reduction in viability of both cell types was produced by palmitic, stearic or arachidic acids, but only after exposures of from 12 to 36 h. These FFA also produced needle-like cytoplasmic inclusions. Mitochondria and lysosomes were labilized after shorter exposures. Capric, lauric and myristic acids, were relatively non-toxic, and protected endothelioid cell lysosomes from labilization.
比较了癸酸（C10:0）、月桂酸（C12:0）、肉豆蔻酸（C14:0）、棕榈酸（C16:0）、硬脂酸（C18:0）和花生酸（C20:0）对培养的大鼠心肌细胞和内皮样细胞的毒性作用。游离脂肪酸（FFA）与白蛋白按6:1比例混合，并以5×10⁻⁵M的浓度进行测试。以细胞活力降低（⁵¹Cr释放）以及原位线粒体和溶酶体的不稳定作为损伤指标。棕榈酸、硬脂酸或花生酸均可导致两种细胞类型的活力降低，但仅在暴露12至36小时后才出现。这些游离脂肪酸还产生针状细胞质内含物。较短时间暴露后线粒体和溶酶体就会变得不稳定。癸酸、月桂酸和肉豆蔻酸相对无毒，并可保护内皮样细胞溶酶体不发生不稳定。
