甲基汞对血清和尿液某些成分的影响。

Effect of methylmercury on some constituents of serum and urine.

作者信息

Planas-Bohne F

出版信息

Toxicology. 1978 Oct;11(2):203-6. doi: 10.1016/s0300-483x(78)91239-8.

Abstract

To evaluate some of the early effects of methymercury chloride (MMC) male rats were given 10, 20 or 30 mg MMC/kg intraperitoneally. Urine was analysed for vanilmandelic acid (VMA), leucine aminopeptidase (LAP), alkaline phosphatase (AP), and creatinine, blood for glucose-6-phosphatase (G-6-P) and glucose, serum for glutamate-oxalate-transaminase (GOT) and urea. Except for LAP and AP excretion there is no effect of MMC on the parameters investigated. However, the effects on these 2 renal enzymes are to variable to permit their use as a test for MMC toxicity.

摘要

为评估甲基氯化汞（MMC）的一些早期效应，给雄性大鼠腹腔注射10、20或30毫克MMC/千克。分析尿液中的香草扁桃酸（VMA）、亮氨酸氨肽酶（LAP）、碱性磷酸酶（AP）和肌酐，血液中的葡萄糖-6-磷酸酶（G-6-P）和葡萄糖，血清中的谷氨酸草酰乙酸转氨酶（GOT）和尿素。除LAP和AP排泄外，MMC对所研究的参数没有影响。然而，对这两种肾酶的影响变化太大，无法将其用作MMC毒性的检测指标。