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[丙酮酸激酶缺乏所致溶血性贫血病例中的血管并发症]

[Vascular complications in a case of hemolytic anemia due to pyruvate kinase deficiency].

作者信息

Bertrand P, Feremans W W, Barroy J P, Dereume J P, Goldstein M

出版信息

Acta Chir Belg. 1982 Nov-Dec;82(6):533-7.

PMID:7158182
Abstract

A rare case of congenital non-spherocytic hemolytic anemia due to pyruvate kinase deficiency is reported. Of particular interest is the never before in the literature mentioned complication of migratory phlebitis and acute thrombosis of the left lower limb associated with trophic changes of the foot. Arteriography disclosed thrombosis of all three calf arteries. The patient was treated by lumbar sympathectomy combined with streptokinase fibrinolysis and resulted in healing of the trophic changes. The distal location of the vascular lesions made direct vascular reconstruction illusory. Fogarty thrombectomy is not indicated either due to the thrombotic nature of the lesions in association with thrombocytosis.

摘要

报告了一例罕见的因丙酮酸激酶缺乏导致的先天性非球形细胞溶血性贫血病例。特别值得关注的是文献中从未提及的与足部营养改变相关的游走性静脉炎和左下肢急性血栓形成的并发症。动脉造影显示三条小腿动脉均有血栓形成。该患者接受了腰交感神经切除术联合链激酶溶栓治疗,足部营养改变得以治愈。血管病变的远端位置使直接血管重建变得不切实际。由于病变的血栓性质以及血小板增多症,也不适合进行Fogarty血栓切除术。

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