Hammer M, Engell H C
Acta Endocrinol (Copenh). 1982 Dec;101(4):517-23. doi: 10.1530/acta.0.1010517.
The plasma arginine vasopressin concentration (pAVP) was measured in blood samples obtained from an internal jugular vein of 8 patients who underwent surgery for a carotid artery stenosis. Ten blood samples were taken with 1 min interval during the operation. Arterial pAVP was measured in 10 simultaneous samples from a radial artery and the brain venoarterial difference of pAVP was calculated. The venoarterial difference was 0-3 pg/ml in 7 of the patients, while it increased to 35 pg/ml upon baroreceptor stimulation in one patient. A pulsatile pattern was found in the veno-arterial difference of pAVP both at low and higher peripheral pAVP levels. This appeared to reflect a discontinuous release of AVP from the neurohypophysis. The described method results in a more accurate picture of ongoing secretory activity than can be obtained by measurements of peripheral pAVP alone. The general usefulness of the method, however, is restricted by the need of a multitude of samples and the difficult approach to the internal jugular vein.
在8例因颈动脉狭窄接受手术的患者中，从颈内静脉采集血样，测定血浆精氨酸加压素浓度（pAVP）。手术期间每隔1分钟采集10份血样。同时从桡动脉采集10份血样测定动脉pAVP，并计算pAVP的脑静脉-动脉差值。7例患者的静脉-动脉差值为0 - 3 pg/ml，而1例患者在压力感受器刺激后该差值增至35 pg/ml。在较低和较高外周pAVP水平时，pAVP的静脉-动脉差值均呈现出搏动模式。这似乎反映了神经垂体中AVP的间断释放。与仅通过测量外周pAVP相比，所述方法能更准确地反映正在进行的分泌活动。然而，该方法的普遍实用性受到需要大量样本以及颈内静脉穿刺困难的限制。
