Yoshikawa T, Takemura S, Kondo M
Acta Vitaminol Enzymol. 1982;4(4):311-8.
Serum levels of alpha-tocopherol (vitamin E) were determined in various types of liver diseases, and as a results, it was revealed that serum alpha-tocopherol was significantly depressed in acute hepatitis (p less than 0.01, n = 22), alcoholic hepatitis (p less than 0.001, n = 9) and fulminant hepatitis (p less than 0.001, n = 6). There was a significant correlation between serum levels of alpha-tocopherol and beta-lipoprotein (r = 0.92, p less than 0.001, n = 17). Though there was no correlation between serum levels of alpha-tocopherol and triglyceride, there was a significant correlation between alpha-tocopherol and cholesterol (r = 0.57, p less than 0.01, n = 21), and phospholipid (r = 0.49, p less than 0.05, n = 18). There was no correlation between serum levels of alpha-tocopherol and other liver function tests. These facts suggested that the diminished serum vitamin E in patients with liver diseases is ascribable to the depression in blood level of beta-lipoprotein that results from liver disorders, because the liver is the major supply source of beta-lipoprotein.
测定了各类肝病患者血清中α-生育酚（维生素E）的水平，结果显示，急性肝炎（p<0.01，n = 22）、酒精性肝炎（p<0.001，n = 9）和暴发性肝炎（p<0.001，n = 6）患者血清中的α-生育酚水平显著降低。血清α-生育酚水平与β-脂蛋白之间存在显著相关性（r = 0.92，p<0.001，n = 17）。虽然血清α-生育酚水平与甘油三酯之间无相关性，但α-生育酚与胆固醇（r = 0.57，p<0.01，n = 21）及磷脂（r = 0.49，p<0.05，n = 18）之间存在显著相关性。血清α-生育酚水平与其他肝功能检查结果之间无相关性。这些事实表明，肝病患者血清维生素E水平降低是由于肝脏疾病导致血液中β-脂蛋白水平下降所致，因为肝脏是β-脂蛋白的主要供应来源。
