慢性肝病中的血清脂质和脂蛋白

Serum lipids and lipoproteins in chronic liver disease.

作者信息

Fehér J, Romics L, Jakab L, Fehér E, Szilvási I, Papp G

出版信息

Acta Med Acad Sci Hung. 1976;33(3):217-23.

Abstract

Serum cholesterol, triglyceride, total lipids and the lipoprotein pattern were studied in 169 cases chronic liver disease confirmed by biopsy. On the ground of the immunological and morphological results the patients were classified into five groups. In chronic persistent hepatitis no significant abnormality was found. In chronic aggressive hepatitis and in cirrhosis of the liver the serum cholesterol level was significantly reduced. In fatty infiltration of the liver the serum cholesterol, triglyceride and total lipid concentrations were significantly increased, as compared with the normal values and with the figures obtained in the cases of chronic inflammatory liver disease. In the cases of cirrhosis with additional diabetes the lipid values were likewise increased. In chronic aggressive hepatitis and in cirrhosis of the liver the levels of pre-beta and alpha lipoprotein were decreased, in fatty infiltration of the liver those of beta and pre-beta lipoprotein were increased.

摘要

对经活检确诊的169例慢性肝病患者的血清胆固醇、甘油三酯、总脂质和脂蛋白模式进行了研究。根据免疫学和形态学结果，将患者分为五组。在慢性持续性肝炎中未发现明显异常。在慢性活动性肝炎和肝硬化中，血清胆固醇水平显著降低。与正常值以及慢性炎症性肝病患者的数值相比，在肝脂肪浸润中，血清胆固醇、甘油三酯和总脂质浓度显著升高。在合并糖尿病的肝硬化病例中，脂质值同样升高。在慢性活动性肝炎和肝硬化中，前β脂蛋白和α脂蛋白水平降低，在肝脂肪浸润中，β脂蛋白和前β脂蛋白水平升高。