头孢羟氨苄和头孢克洛在八天给药期内的药代动力学。
Pharmacokinetics of cefadroxil and cefaclor during an eight-day dosage period.
作者信息
Hampel B, Lode H, Wagner J, Koeppe P
出版信息
Antimicrob Agents Chemother. 1982 Dec;22(6):1061-3. doi: 10.1128/AAC.22.6.1061.
Abstract
The concentrations of cefadroxil and cefaclor in serum were studied in eight healthy volunteers receiving 1,000 mg of both substances three times per day for 8 days. Intraindividual comparisons showed an increase in peak serum levels of cefadroxil from days 1 to 8 in seven of eight volunteers. Cefaclor peak concentrations did not rise during the 8 days.
摘要
对8名健康志愿者进行了研究，他们每天3次服用1000毫克头孢羟氨苄和头孢克洛，持续8天，以测定血清中这两种药物的浓度。个体内比较显示，8名志愿者中有7名的头孢羟氨苄血清峰值水平从第1天到第8天有所升高。头孢克洛的峰值浓度在8天内未升高。
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