头孢克洛在志愿者中的药理学评估。
Pharmacological evaluation of cefaclor in volunteers.
作者信息
Hodges G R, Liu C, Hinthorn D R, Harms J L, Dworzack D L
出版信息
Antimicrob Agents Chemother. 1978 Sep;14(3):454-6. doi: 10.1128/AAC.14.3.454.
Abstract
The plasma and urine concentrations of cefaclor were measured after oral administration of single and multiple doses to volunteers. Cefaclor was rapidly absorbed, rapidly excreted in the urine, well tolerated without toxicity, and failed to accumulate in the plasma with chronic dosing.
摘要
对志愿者单次和多次口服头孢克洛后，测定了其血浆和尿液浓度。头孢克洛吸收迅速，经尿液快速排泄，耐受性良好且无毒性，长期给药后血浆中不会蓄积。
相似文献
1
Pharmacological evaluation of cefaclor in volunteers.头孢克洛在志愿者中的药理学评估。
Antimicrob Agents Chemother. 1978 Sep;14(3):454-6. doi: 10.1128/AAC.14.3.454.
2
Phase I study of multiple-dose cefprozil and comparison with cefaclor.多剂量头孢丙烯的I期研究及其与头孢克洛的比较。
Antimicrob Agents Chemother. 1990 Jun;34(6):1198-203. doi: 10.1128/AAC.34.6.1198.
3
Comparative pharmacology of cefaclor and cephalexin.头孢克洛与头孢氨苄的比较药理学
Antimicrob Agents Chemother. 1977 Aug;12(2):157-62. doi: 10.1128/AAC.12.2.157.
4
Pharmacologic studies with cefaclor, a new oral cephalosporin.
J Clin Pharmacol. 1978 Apr;18(4):174-9. doi: 10.1002/j.1552-4604.1978.tb01590.x.
5
Pharmacokinetic profile of cefaclor.头孢克洛的药代动力学特征。
Int J Clin Pharmacol Ther. 1997 Sep;35(9):374-80.
6
Pharmacology of cefaclor in normal volunteers and patients with renal failure.头孢克洛在正常志愿者和肾衰竭患者中的药理学。
Antimicrob Agents Chemother. 1978 Jun;13(6):951-4. doi: 10.1128/AAC.13.6.951.
7
The pharmacokinetics of the oral cephalosporins cefaclor, cephradine and cephalexin.
Int J Clin Pharmacol Biopharm. 1979 Sep;17(9):397-400.
8
Pharmacokinetics of cefaclor and cephalexin: dosage nomograms for impaired renal function.头孢克洛和头孢氨苄的药代动力学：肾功能受损时的剂量列线图
Antimicrob Agents Chemother. 1978 Aug;14(2):172-7. doi: 10.1128/AAC.14.2.172.
9
A pharmacological and in vitro comparison of three oral cephalosporins.
J Antimicrob Chemother. 1979 Sep;5(5):601-7. doi: 10.1093/jac/5.5.601.
10
Comparison of cefprozil and cefaclor pharmacokinetics and tissue penetration.头孢丙烯与头孢克洛的药代动力学及组织穿透性比较。
Antimicrob Agents Chemother. 1990 Jun;34(6):1204-9. doi: 10.1128/AAC.34.6.1204.
引用本文的文献
1
The effect of four different types of diet on the bioavailability of loracarbef.四种不同类型的饮食对氯碳头孢生物利用度的影响。
Eur J Drug Metab Pharmacokinet. 2007 Oct-Dec;32(4):205-11. doi: 10.1007/BF03191005.
2
Comparative effect of different types of food on the bioavailability of cefaclor extended release tablet.不同类型食物对头孢克洛缓释片生物利用度的比较影响。
Eur J Drug Metab Pharmacokinet. 2004 Apr-Jun;29(2):125-32. doi: 10.1007/BF03190587.
3
The effect of four different types of food on the bioavailability of cefaclor.四种不同类型食物对头孢克洛生物利用度的影响。
Eur J Drug Metab Pharmacokinet. 2003 Jul-Sep;28(3):185-90. doi: 10.1007/BF03190484.
4
Effects of prophylactic administration of cefaclor on transient bacteremia after dental extraction.头孢克洛预防性给药对拔牙后短暂菌血症的影响。
Eur J Clin Microbiol Infect Dis. 1996 Aug;15(8):646-9. doi: 10.1007/BF01691150.
5
Pharmacokinetics of cefadroxil and cefaclor during an eight-day dosage period.头孢羟氨苄和头孢克洛在八天给药期内的药代动力学。
Antimicrob Agents Chemother. 1982 Dec;22(6):1061-3. doi: 10.1128/AAC.22.6.1061.
6
Single oral dose of cefaclor for the treatment of infections with penicillinase-producing strains of Neisseria gonorrhoeae.单次口服头孢克洛治疗产青霉素酶淋病奈瑟菌感染。
Br J Vener Dis. 1982 Jun;58(3):176-9. doi: 10.1136/sti.58.3.176.
7
Penetration of cefaclor into bronchial mucosa.头孢克洛在支气管黏膜中的渗透情况。
Thorax. 1984 Nov;39(11):813-7. doi: 10.1136/thx.39.11.813.
8
Single-dose cefuroxime axetil versus multiple-dose cefaclor in the treatment of acute urinary tract infections.单剂量头孢呋辛酯与多剂量头孢克洛治疗急性尿路感染的比较。
Antimicrob Agents Chemother. 1989 Aug;33(8):1212-6. doi: 10.1128/AAC.33.8.1212.
9
Comparison of the effects of food on the pharmacokinetics of cefprozil and cefaclor.食物对头孢丙烯和头孢克洛药代动力学影响的比较。
Antimicrob Agents Chemother. 1990 Jun;34(6):1210-3. doi: 10.1128/AAC.34.6.1210.
10
Comparison of cefprozil and cefaclor pharmacokinetics and tissue penetration.头孢丙烯与头孢克洛的药代动力学及组织穿透性比较。
Antimicrob Agents Chemother. 1990 Jun;34(6):1204-9. doi: 10.1128/AAC.34.6.1204.
本文引用的文献
1
In vitro activities of five oral cephalosporins against aerobic pathogenic bacteria.五种口服头孢菌素对需氧病原菌的体外活性
Antimicrob Agents Chemother. 1977 Nov;12(5):609-13. doi: 10.1128/AAC.12.5.609.
2
In vitro studies with cefaclor, a new oral cephalosporin.使用新型口服头孢菌素头孢克洛进行的体外研究。
Antimicrob Agents Chemother. 1977 Oct;12(4):490-7. doi: 10.1128/AAC.12.4.490.
3
In vitro activity of cefaclor, a new orally administered cephalosporin antibiotic.新型口服头孢菌素抗生素头孢克洛的体外活性
Antimicrob Agents Chemother. 1977 Sep;12(3):442-3. doi: 10.1128/AAC.12.3.442.
4
In vitro susceptibility studies with cefaclor and cephalexin.头孢克洛和头孢氨苄的体外药敏试验
Antimicrob Agents Chemother. 1977 Aug;12(2):290-2. doi: 10.1128/AAC.12.2.290.
5
Comparative pharmacology of cefaclor and cephalexin.头孢克洛与头孢氨苄的比较药理学
Antimicrob Agents Chemother. 1977 Aug;12(2):157-62. doi: 10.1128/AAC.12.2.157.
6
Comparison of in vitro activity of cephalexin, cephradine, and cefaclor.头孢氨苄、头孢拉定和头孢克洛的体外活性比较。
Antimicrob Agents Chemother. 1977 Mar;11(3):470-4. doi: 10.1128/AAC.11.3.470.
Zotero 插件