Garagorri J M, Chaussain J L, Job J C
Arch Fr Pediatr. 1982 Oct;39(8):605-11.
A study of 98 cases of true sexual precocity in girls shows a frequency three times higher between 5 and 7 years than before age 5. Detectable causes (intracranial lesion and Mac Cune-Albright syndrome) were found in 56% of cases before 5 years and only 18% after age 5. The plasma levels of estradiol and gonadotropins and the gonadotropins response to LHRH did not differ significantly from those found at the corresponding stages of normal puberty. Plasma dehydroepiandrosterone was lower. Pelvic ultrasonography sometimes discovered follicular cysts. 44 patients treated with medroxyprogesterone acetate were followed for one or several years. Results on sexual development and plasma estradiol were good in most of them, with individual variations, Improvement in the ratio of bone age as height age and in the expected adult height was obtained but without statistical significance.
一项对98例女童真性性早熟的研究表明，5至7岁女童的发病率比5岁前高出两倍。5岁前56%的病例可查出病因（颅内病变和麦库恩-奥尔布赖特综合征），5岁后仅为18%。雌二醇和促性腺激素的血浆水平以及促性腺激素对促黄体生成素释放激素（LHRH）的反应与正常青春期相应阶段无显著差异。血浆脱氢表雄酮水平较低。盆腔超声检查有时可发现滤泡囊肿。44例接受醋酸甲羟孕酮治疗的患者随访了一年或数年。大多数患者的性发育和血浆雌二醇结果良好，但存在个体差异。骨龄与身高年龄之比以及预期成人身高有所改善，但无统计学意义。
