Kireeva S G, Selitskaia R P
Arkh Patol. 1982;44(11):38-43.
When levamisol was added to the antituberculosis therapy of rabbits with destructive pulmonary tuberculosis, intensive infiltration of the zone of lesions with polymorphonuclear cells and their accumulation in cavities, increased numbers of giant multinuclear cells, "macrophage" transformation of epithelioid cells were observed; the caverns had one-layer connective tissue wall or underwent scarring. In treatment with levamisol alone the same morphological features were observed, however, without complete disappearance of the signs of specific inflammation and abacillation in all the animals. The animals given antituberculosis therapy alone retained the signs of specific inflammation despite abacillation. Changes in inflammation morphology under the influence of levamisol characterize it as a histomodulator and indicate (considering cholinergic and thymomimetic effect of levamisol) a difference in biochemical and immunological mechanisms of chronic specific and acute nonspecific inflammation.
当左旋咪唑添加到患有破坏性肺结核的兔子的抗结核治疗中时，观察到病变区域有多形核细胞的密集浸润及其在空洞中的积聚，巨大多核细胞数量增加，上皮样细胞发生“巨噬细胞”转化；空洞有一层结缔组织壁或形成瘢痕。单独使用左旋咪唑治疗时也观察到相同的形态学特征，然而，并非所有动物的特异性炎症和脱屑迹象都完全消失。单独接受抗结核治疗的动物尽管有脱屑现象，但仍保留特异性炎症的迹象。左旋咪唑影响下炎症形态的变化表明它是一种组织调节剂，并表明（考虑到左旋咪唑的胆碱能和胸腺模拟作用）慢性特异性炎症和急性非特异性炎症在生化和免疫机制上的差异。
