Schnakenberg D D, Rogers Q R
Aviat Space Environ Med. 1982 Dec;53(12):1202-6.
A low cost, gas-dilution type, high-altitude simulator was developed and found to be a useful model for studying the effect of acute hypoxic exposure on food consumption in the rat. A distinct advantage of this system is that it provides access to the animals without disturbance to the gaseous atmosphere. The onset of hypoxic hypophagia was shown to occur within the first 3 h following abrupt ascent to a simulated altitude of 4419.6 m (14,500 ft). The magnitude of the anorexic effect was uniform throughout the first day of exposure to 12% O2; likewise, food consumption rapidly recovered following return to a sea level atmosphere. It was concluded that the hypophagic effect of hypoxia is not absolute and that the severity of the hypophagia can be reduced by prior food deprivation. However, the degree of attenuation of the hypophagic response was not directly related to the length of the deprivation period. Food deprivation may sufficiently enhance metabolic-induced food demand signals to partially override the inhibitory effect of hypoxia on feeding behavior. Alternatively, metabolic perturbations associated with the food-deprived state may, in some undefined manner, minimize the severity of acute hypoxic stress.
开发了一种低成本、气体稀释型的高原模拟器，发现它是研究急性低氧暴露对大鼠食物消耗影响的有用模型。该系统的一个显著优点是，在不干扰气体氛围的情况下就能接触到动物。研究表明，在突然上升到模拟海拔4419.6米（14,500英尺）后的最初3小时内，就会出现低氧性摄食减少。在暴露于12%氧气的第一天，厌食效应的程度是一致的；同样，回到海平面大气后，食物消耗迅速恢复。得出的结论是，低氧的摄食减少效应不是绝对的，并且预先禁食可以减轻摄食减少的严重程度。然而，摄食减少反应的减弱程度与禁食期的长短没有直接关系。禁食可能会充分增强代谢诱导的食物需求信号，从而部分抵消低氧对摄食行为的抑制作用。或者，与禁食状态相关的代谢紊乱可能以某种未明确的方式，将急性低氧应激的严重程度降至最低。
