Groza P, Ionescu S T, Olteanu F L
Physiologie. 1985 Apr-Jun;22(2):89-101.
The authors of this article studied the influence of hypoxia, on thirteen groups of male rats, at altitudes of 2 200 m; 5 000 m; and 8 000 m assimilated in a barochamber by chronic or acute exposure (from 2 hours to 21 days) upon the parameters of acid-base equilibrium. The data obtained demonstrated the development of gaseous alkalosis, which is directly proportional to the altitude and time of exposure, hypocapnia, a decrease in excess base and actual bicarbonate, as well as decreased in oxygen pressure. Adrenalin and noradrenalin administered intraperitoneally produced an acidotic effect. Adrenalectomized animals exposed to hypoxia developed mixed alkalosis-respiratory and metabolic reaction.
本文作者研究了在2200米、5000米和8000米海拔高度下，通过慢性或急性暴露（2小时至21天）将13组雄性大鼠置于气压舱中，低氧对酸碱平衡参数的影响。获得的数据表明出现了气体性碱中毒，其与海拔高度和暴露时间成正比，同时伴有低碳酸血症、碱剩余和实际碳酸氢盐降低，以及氧分压降低。腹腔注射肾上腺素和去甲肾上腺素会产生酸中毒作用。肾上腺切除的动物暴露于低氧环境会出现混合性碱中毒——呼吸性和代谢性反应。
