Greenhill N S, Stehbens W E
Atherosclerosis. 1982 Dec;45(3):319-30. doi: 10.1016/0021-9150(82)90233-7.
A scanning electron-microscopic study of the inner surface of experimental saccular aneurysms in rabbits was conducted to demonstrate the effects of haemodynamics on the aneurysmal wall. Animals with aneurysms were killed from 2 to 83 weeks postoperatively, and the controls from 7 to 51 weeks. In both series, re-endothelialization was complete in approximately 2 weeks. In control tissue endothelium was normal, and sutures caused mild distortion of the luminal surface. In the aneurysms, there were tracts of spindle-shaped cells, often arranged in whorl-like patterns and interspersed with regions of polyhedral cells with thickened intercellular borders, prominent stomata and numerous microvilli. In some areas, long filamentous intercellular processes were prominent. The few jet lesions seen were covered with polyhedral cells and were less complex than those in arteriovenous fistulae. Ridges, caused by elevated subendothelial connective tissues were crescentic or circular, outlining depressions and craters, as if delineating vortices. The carotid artery opposite the aneurysm exhibited endothelium similar to normal tissue, except in older aneurysms where corrugations caused by the internal elastic lamina were completely or partially absent. The experiments demonstrate the effect of intra-aneurysmal haemodynamics on the topography of the endothelium and subendothelial tissues of the sac wall, and support the concept that endothelial topography in the vascular system under physiological conditions is haemodynamically determined.
对兔实验性囊状动脉瘤内表面进行扫描电子显微镜研究，以证明血流动力学对动脉瘤壁的影响。动脉瘤动物在术后2至83周处死，对照组在7至51周处死。在这两个系列中，再内皮化在大约2周内完成。在对照组织中，内皮正常，缝线导致管腔表面轻度变形。在动脉瘤中，有梭形细胞束，常呈螺旋状排列，并散布着多面体细胞区域，这些细胞的细胞间边界增厚、气孔突出且有许多微绒毛。在一些区域，长丝状细胞间突起很突出。所见的少数喷射性病变被多面体细胞覆盖，且比动静脉瘘中的病变更简单。由内皮下结缔组织升高引起的嵴呈新月形或圆形，勾勒出凹陷和坑洼，仿佛描绘出漩涡。动脉瘤对面的颈动脉内皮与正常组织相似，但在较老的动脉瘤中，内弹性膜引起的皱纹完全或部分缺失。这些实验证明了动脉瘤内血流动力学对囊壁内皮和内皮下组织形态的影响，并支持了生理条件下血管系统中内皮形态由血流动力学决定的概念。
