Eickhoff J H, Jacobsen E
Biotelem Patient Monit. 1982;9(3):175-84.
Whether transcutaneous oxygen tension (TcPO2) is independent of minor variations in perfusion under the TcPO2 electrode, as is claimed, was studied in 18 feet of 16 young healthy adults. The TcPO2 electrode was mounted on the dorsum of the foot and operated at 43 degrees C, while the blood pressure was changed by elevating and lowering the foot. During elevation the mean arterial blood pressure decreased corresponding to the hydrostatic pressure of the column of blood between the heart and the position of the foot. In every experiment TcPO2 decreased when the foot was elevated at an average rate of 1.2% per millimeter Hg change in mean arterial blood pressure. TcPO2 was negatively correlated to blood flow in normal unheated tissue, but significantly and positively correlated to blood flow in the heated, vasodilated tissue under the TcPO2 electrode. In the heated tissue normal blood flow regulation was abolished, and the perfusion under the electrode was mainly determined by the arterial blood pressure. It is concluded that TcPO2 in adults--and probably also in neonates--is affected by the minor or large variations in the perfusion under the electrode caused by fluctuations in arterial blood pressure.
16名年轻健康成年人的18只脚被用于研究经皮氧分压（TcPO2）是否如所声称的那样，不受TcPO2电极下灌注的微小变化影响。将TcPO2电极安装在足背，在43摄氏度下操作，同时通过抬高和降低足部来改变血压。抬高足部时，平均动脉血压下降，下降幅度与心脏和足部位置之间血柱的静水压力相对应。在每个实验中，当足部抬高时，TcPO2下降，平均动脉血压每变化1毫米汞柱，TcPO2平均下降率为1.2%。在正常未加热组织中，TcPO2与血流呈负相关，但在TcPO2电极下加热、血管扩张的组织中，TcPO2与血流呈显著正相关。在加热组织中，正常的血流调节被消除，电极下的灌注主要由动脉血压决定。得出的结论是，成年人——可能还有新生儿——的TcPO2会受到动脉血压波动引起的电极下灌注微小或较大变化的影响。
