Struhl G, Brower D
Cell. 1982 Nov;31(1):285-92. doi: 10.1016/0092-8674(82)90428-7.
Recent studies of the esc+ gene suggest that its product acts principally in the initiation, but not the maintenance, of segmental determination. We have tested this hypothesis by examining when the esc+ gene product is required during embryogenesis, and whether the esc+ gene product is required for the stable determination of imaginal disc cells passaged in in vivo culture. We find that the esc+ gene product is required during a discrete period of embryogenesis. If the gene product is absent or inactive during this period, most segments develop like the eighth abdominal segment. In contrast, absence of active gene product before or after this period has relatively little effect on segmental development. These results support the hypothesis that the esc+ gene product has a discrete early function in the initiation of segmental determination.
最近对esc+基因的研究表明，其产物主要在体节决定的起始阶段发挥作用，而不是在维持阶段。我们通过研究胚胎发育过程中何时需要esc+基因产物，以及esc+基因产物对于体内培养传代的成虫盘细胞的稳定决定是否必要，来验证这一假设。我们发现，esc+基因产物在胚胎发育的一个特定时期是必需的。如果在此期间该基因产物缺失或无活性，大多数体节会发育得像第八腹节。相比之下，在此期间之前或之后缺乏活性基因产物对体节发育的影响相对较小。这些结果支持了这样的假设，即esc+基因产物在体节决定的起始阶段具有特定的早期功能。
