Wu R S, Tsai S, Bonner W M
Cell. 1982 Dec;31(2 Pt 1):367-74. doi: 10.1016/0092-8674(82)90130-1.
Quiescent Chinese hamster ovary cells, as well as three other types of quiescent cells, synthesize histone at a reduced but significant rate. The variant patterns of the histone synthesis in quiescent, S-phase and G1-phase and G2-phase cells ali differed from each other. H3.3 was the only H3 variant synthesized in quiescent and in G1 and G2 cells. All four H2A variants were synthesized in quiescent and S-phase cells, but only H2A.X and H2A.Z were synthesized in G1 and G2 cells. No part of G1 or the G1-S transition could be found with an H2A synthesis pattern like that in quiescent cells. These findings suggest that the quiescent state is not part of G1, but that it is a separate and discrete state.
静止的中国仓鼠卵巢细胞以及其他三种静止细胞类型以降低但显著的速率合成组蛋白。静止期、S期、G1期和G2期细胞中组蛋白合成的变异模式彼此不同。H3.3是在静止期以及G1期和G2期细胞中合成的唯一H3变异体。所有四种H2A变异体在静止期和S期细胞中合成，但在G1期和G2期细胞中仅合成H2A.X和H2A.Z。在G1期或G1-S转换中找不到与静止期细胞类似的H2A合成模式。这些发现表明静止状态不是G1期的一部分，而是一个独立且离散的状态。
