Henderson A S, Robins D
Cytogenet Cell Genet. 1982;34(4):310-4. doi: 10.1159/000131822.
We have previously shown that exogenous DNA may be incorporated into host cell chromosomes following DNA-mediated gene transfer (transformation). Discrete chromosomal changes often accompany the integration event. In this study, the effect of integration of DNA that codes for human growth hormone into a region containing ribosomal DNA in rat chromosomes was investigated. The results show that insertion of exogenous DNA results in the inactivation of the ribosomal DNA and a partial deletion of ribosomal DNA sequences.
