Kobayashi J, Nakamura H, Ohizumi Y
Eur J Pharmacol. 1982 Dec 24;86(2):283-6. doi: 10.1016/0014-2999(82)90328-4.
A myotoxin purified from Conus magus venom elicited complete loss of contractile response of the mouse diaphragm to electrical stimulation followed by a gradual rise in the baseline, an increase in the contractile force of the guinea-pig left atria, a tonic contraction of the guniea-pig taenia caeci and powerful rhythmic contractions of the guinea-pig ileum and vas deferens. These excitatory effects of the toxin were blocked by treatment with tetrodotoxin, suggesting that these effects were due to an increase in Na+ permeability of the cell membrane.
从织锦芋螺毒液中纯化出的一种肌毒素，可使小鼠膈肌对电刺激的收缩反应完全丧失，随后基线逐渐升高，豚鼠左心房收缩力增加，豚鼠盲肠带出现强直性收缩，豚鼠回肠和输精管出现强烈的节律性收缩。用河豚毒素处理可阻断该毒素的这些兴奋作用，这表明这些作用是由于细胞膜对钠离子通透性增加所致。
