Heenan P J, Holman C D
Histopathology. 1982 Nov;6(6):703-16. doi: 10.1111/j.1365-2559.1982.tb02765.x.
Two series of cutaneous malignant melanoma (CMM), one from a low incidence area (the Oxford Region) and one from a high incidence area (Western Australia), were compared by one pathologist using the same histological criteria. The findings included similarities in the distributions of histogenetic type of CMM, predominant cell type, and the degree and pattern of inflammatory reaction. Differences were found in other features including tumour profile, the presence of ulceration, mitotic activity, evidence of regression and level of invasion. The most important, and consistent morphological difference was the greater thickness of tumours from the Oxford Region, which is thought to be consistent with the theory that CMM is diagnosed at an earlier stage in high incidence areas because of greater medical and public awareness of the condition. Some problems in the use of accepted classifications of CMM are discussed.
一位病理学家运用相同的组织学标准，对两组皮肤恶性黑色素瘤（CMM）进行了比较，一组来自低发病率地区（牛津地区），另一组来自高发病率地区（西澳大利亚）。研究结果包括CMM组织发生类型的分布、主要细胞类型以及炎症反应的程度和模式等方面的相似性。在其他特征方面也发现了差异，包括肿瘤轮廓、溃疡的存在、有丝分裂活性、消退证据和浸润水平。最重要且一致的形态学差异是牛津地区肿瘤的厚度更大，这被认为与以下理论相符，即由于医疗和公众对该病的认识提高，CMM在高发病率地区能在更早阶段被诊断出来。文中还讨论了在使用公认的CMM分类时存在的一些问题。
