Raju M R, Tokita N
Int J Radiat Oncol Biol Phys. 1982 Dec;8(12):2133-6. doi: 10.1016/0360-3016(82)90557-0.
Recent radiobiology data for pion beams used in therapy are presented. The biological systems used were cultured cells suspended in gelatin and intestinal crypt assay. The importance of fast neutrons from pion stars in large treatment volumes is discussed. The data for compensating the depth dose distribution to produce uniform cell killing across the peak region are presented. The changes in biological effectiveness with peak width for pion beams (unlike heavy ions) are small because of fast neutron contribution from pion stars. The need for innovative radiobiology programs to guide high-LET radiotherapy is discussed.
本文介绍了近期用于治疗的π介子束的放射生物学数据。所使用的生物系统是悬浮在明胶中的培养细胞和肠道隐窝试验。讨论了π介子星产生的快中子在大治疗体积中的重要性。给出了补偿深度剂量分布以在峰值区域产生均匀细胞杀伤的数据。由于π介子星的快中子贡献，π介子束（与重离子不同）的生物有效性随峰值宽度的变化很小。讨论了开展创新放射生物学计划以指导高LET放射治疗的必要性。
