Jones W N, Perrier D, Trinca C E, Hager W D, Conrad K
J Clin Pharmacol. 1982 Nov-Dec;22(11-12):543-50. doi: 10.1002/j.1552-4604.1982.tb02647.x.
The ability to precisely predict serum digoxin concentrations using 12 published methods in a group of 85 patients was undertaken. Two methods of estimating creatinine clearance and two estimates of ideal body weight were employed as input variables using the 12 dosing methods. This resulted in 40 relationships from which correlation coefficients and linear regression constants were derived for predicted versus measured serum digoxin concentrations. The correlation coefficients between predicted and measured serum digoxin ranged from -0.393 to 0.389. Possible explanations for the low correlation coefficients are interpatient variability in the kinetics of digoxin, the small number of subjects used to generate some of the digoxin dosing methods, undetected patient noncompliance in the present study, the use of empirically derived dosing methods, and/or the use of rather homogeneous patient populations to develop a given method while this study is comprised of a heterogeneous group of patients. The methods studied tend to overpredict serum digoxin concentrations and therefore generally allow safe, first approximations for digoxin dosing.
我们对85名患者使用12种已发表的方法精确预测血清地高辛浓度的能力进行了研究。使用12种给药方法时，采用了两种估算肌酐清除率的方法和两种理想体重的估算值作为输入变量。这产生了40种关系，从中得出预测血清地高辛浓度与实测血清地高辛浓度之间的相关系数和线性回归常数。预测血清地高辛浓度与实测血清地高辛浓度之间的相关系数范围为-0.393至0.389。相关系数较低的可能解释包括：地高辛动力学在患者间存在变异性、用于生成某些地高辛给药方法的受试者数量较少、本研究中未检测到的患者不依从性、使用经验性得出的给药方法，和/或在开发给定方法时使用了相当同质的患者群体，而本研究由一组异质性患者组成。所研究的方法往往会高估血清地高辛浓度，因此通常可为地高辛给药提供安全的初步近似值。
