Larson H E, Parry R P, Tyrrell D A
Br J Dis Chest. 1980 Jan;74(1):56-62.
Polymorphonuclear leucocyte function was assessed in 13 patients with influenza by measuring phagocytosis of staphylococci and chemotaxis. Significant impairment of chemotaxis was shown. Subsequeuntly polymorph chemotaxis was found to be impaired in a group of volunteers infected with virus recombinants of A/New Jersey/8/76 but not in volunteers infected with a virus recombinant of A/Victoria/3/75. These results accord well with the in vitro effects of certain influenza viruses on polymorph function and suggest that interference with polymorph function may predispose to bacterial pneumonia after clinical influenza.
通过测量葡萄球菌的吞噬作用和趋化性，对13名流感患者的多形核白细胞功能进行了评估。结果显示趋化性有显著损害。随后发现，一组感染了A/新泽西/8/76病毒重组体的志愿者的多形核趋化性受损，但感染A/维多利亚/3/75病毒重组体的志愿者则未出现这种情况。这些结果与某些流感病毒对多形核白细胞功能的体外影响非常吻合，并表明多形核白细胞功能受到干扰可能会使临床流感后易患细菌性肺炎。
