Fiocchi R, Bianchi G, Petrillo P, Tavani A, Manara L
Life Sci. 1982;31(20-21):2221-3. doi: 10.1016/0024-3205(82)90123-0.
The effect of a single dose of morphine on small intestinal transit was studied in fasted rats by feeding a charcoal test meal either by stomach tube to normal animals or through a duodenal cannula to chronically implanted rats. The percentage of small intestine traversed by charcoal in 5 min was reduced by morphine (0.7 mg/kg s.c.) given 5 min before the meal to a similar extent in normal and implanted rats. In contrast administration of atropine (0.8 mg/kg s.c.) 30 min before the meal reduced charcoal transit only in normal rats fed the test meal by stomach tube. Inhibition of gastrointestinal transit in the rat by systemically administered morphine is mainly due to impaired small intestinal propulsion and does not depend to any significant extent on a direct action on the stomach delaying gastric emptying.
通过给禁食大鼠经胃管投喂炭末测试餐（用于正常动物）或经十二指肠插管投喂给长期植入的大鼠，研究了单剂量吗啡对小肠转运的影响。在餐前5分钟给予吗啡（0.7mg/kg皮下注射），正常大鼠和植入大鼠在5分钟内炭末在小肠中移动的百分比均有类似程度的降低。相比之下，在餐前30分钟给予阿托品（0.8mg/kg皮下注射），仅在经胃管投喂测试餐的正常大鼠中减少了炭末转运。全身给药的吗啡对大鼠胃肠转运的抑制主要是由于小肠推进功能受损，在很大程度上并不依赖于对胃延迟胃排空的直接作用。
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