通过乳果糖氢呼气试验评估洛哌丁胺和纳洛酮对口腔至盲肠转运时间的影响。
Effect of loperamide and naloxone on mouth-to-caecum transit time evaluated by lactulose hydrogen breath test.
作者信息
Basilisco G, Bozzani A, Camboni G, Recchia M, Quatrini M, Conte D, Penagini R, Bianchi P A
出版信息
Gut. 1985 Jul;26(7):700-3. doi: 10.1136/gut.26.7.700.
Abstract
The effect of loperamide and naloxone on mouth-to-caecum transit time was evaluated by the lactulose hydrogen breath test in four men and four women. Each subject underwent tests during the administration of placebo, loperamide (12-16 mg po), naloxone (40 micrograms/kg/h by a three-hour intravenous infusion), and loperamide plus naloxone, carried out at intervals of one or two weeks. The transit time was significantly longer after loperamide, and this effect was antagonised by the concomitant administration of naloxone whereas naloxone administered alone had no effect on mean transit time. No clinically important side effects were reported.
摘要
通过乳果糖氢呼气试验，对4名男性和4名女性评估了洛哌丁胺和纳洛酮对口至盲肠转运时间的影响。每位受试者在服用安慰剂、洛哌丁胺（口服12 - 16毫克）、纳洛酮（通过三小时静脉输注，40微克/千克/小时）以及洛哌丁胺加纳洛酮期间接受测试，测试间隔为一或两周。服用洛哌丁胺后转运时间显著延长，而同时服用纳洛酮可拮抗这一作用，单独服用纳洛酮对平均转运时间无影响。未报告有临床重要的副作用。
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