甲硫氨酸脑啡肽-精氨酸6-苯丙氨酸7（MEAP）在大鼠和豚鼠各组织中的分布。
Distribution of met5-enkephalin-Arg6-Phe7 (MEAP) in various tissues of rats and guinea pigs.
作者信息
Tang J, Yang H Y, Costa E
出版信息
Life Sci. 1982;31(20-21):2303-6. doi: 10.1016/0024-3205(82)90143-6.
With a specific and sensitive radioimmunoassay coupled to HPLC separation, we have measured met5-enkephalin-Arg6-Phe7 in extracts of various peripheral organs. The highest content was found in ileum and lung. The MEAP in lung can be released in a Ca++-dependent manner by KCl. The ratio of MEAP/ME seems to differ in various peripheral tissues, suggesting that MEAP may not only be a precursor of ME but may also act as a neurotransmitter or neuromodulator itself.
通过一种与高效液相色谱分离相结合的特异性和灵敏的放射免疫分析法，我们测定了各种外周器官提取物中的甲硫氨酸脑啡肽-精氨酸6-苯丙氨酸7。在回肠和肺中发现含量最高。肺中的甲硫氨酸脑啡肽-精氨酸6-苯丙氨酸7可通过氯化钾以钙离子依赖的方式释放。甲硫氨酸脑啡肽-精氨酸6-苯丙氨酸7/甲硫氨酸脑啡肽的比值在各种外周组织中似乎有所不同，这表明甲硫氨酸脑啡肽-精氨酸6-苯丙氨酸7可能不仅是甲硫氨酸脑啡肽的前体，还可能本身作为一种神经递质或神经调节剂发挥作用。
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