Cianciara M, Bobilewicz D, Kotlicka J
Med Pr. 1982;33(4):199-209.
The studies covered 60 men (average age 43.5 +/- 6.5 years), carrying on managerial functions (average length of employment 8.3 +/- 2.5 years). All subjects underwent standard determinations of total cholesterol (Liebermann--Burchard's method) and triglycerides (using Boehringer's enzymatic set) and lypoproteins electrophoretic distribution on polyacrylamid gel (Ames' firm). In 31 subjects lypoproteins distribution was performed, through precipitation, into fractions HDL, LDL and HLDL, in which the contents of cholesterol and triglycerides have been determined. In 40% of subjects, hyperlypoproteidemia, type IV (HL-IV) has been found, which would indicate the advisability to cover the managerial personnel by such studies. The HL-IV has been found to be accompanied by an extreme increase of VLDL fraction triglycerides and a significant increase of cholesterol of this fraction. Moreover, the HDL cholesterol concentration has been found to be decreased, as compared to normolypo-proteidemia. The results of electrophoretic distribution indicated a good correlation with the results of total triglycerides in blood serum.
这些研究涵盖了60名男性（平均年龄43.5±6.5岁），他们担任管理职务（平均工作年限8.3±2.5年）。所有受试者均接受了总胆固醇（利伯曼-布查德法）、甘油三酯（使用勃林格酶试剂盒）的标准测定以及在聚丙烯酰胺凝胶上的脂蛋白电泳分布测定（艾姆斯公司）。在31名受试者中，通过沉淀法将脂蛋白分布为HDL、LDL和HLDL组分，并测定了其中胆固醇和甘油三酯的含量。在40%的受试者中发现了IV型高脂蛋白血症（HL-IV），这表明应对管理人员进行此类研究。已发现HL-IV伴有极低密度脂蛋白（VLDL）组分甘油三酯的极度升高以及该组分胆固醇的显著增加。此外，与正常脂蛋白血症相比，高密度脂蛋白（HDL）胆固醇浓度降低。电泳分布结果与血清总甘油三酯结果具有良好的相关性。
