Pappová N, Siracká E, Vacek A, Durkovský J
Neoplasma. 1982;29(6):669-74.
Serial polarographic measurement of the tissue oxygen tension (pO2) was made in the course of fractionated irradiation (preoperative or sole treatment) of advanced breast cancer in 24 patients. In responsive tumors increase in pO2 appeared sooner before expressive tumor size reduction became noticeable. Repeated recording of unchanged pO2 values has proved to be a good prognostic indicator of local failure. The study made on this tumor model has shown that serial polarographic pO2 determinations with suitable electrodes causing minimal trauma and providing consistent and reproductive data about changes in tumor microcirculation and oxygenation, may enlarge the scale of indicators of the radiation response.
对24例晚期乳腺癌患者在分次照射（术前或单纯治疗）过程中进行了组织氧张力（pO2）的系列极谱测量。在反应性肿瘤中，pO2升高比明显的肿瘤大小缩小出现得更早。多次记录到pO2值不变已被证明是局部失败的良好预后指标。对该肿瘤模型的研究表明，使用造成最小创伤并能提供关于肿瘤微循环和氧合变化的一致且可重复数据的合适电极进行系列极谱pO2测定，可能会扩大辐射反应指标的范围。
