Wood W G, Armbrecht H J
Neurobiol Aging. 1982 Fall;3(3):243-6. doi: 10.1016/0197-4580(82)90046-x.
This experiment examined the effects of ethanol on body temperature and ethanol-induced impairment among three different age groups (8 months, 18 months, and 28 months) of C57BL/6NNIA male mice. Mice were injected intraperitoneally with 3 g/kg ethanol or an equivalent volume of saline. Body temperature, blood ethanol levels, and time when the righting response (RR) was lost and regained were measured. Body temperature also was measured prior to injection and at 30 and 120 min post-injection The aged mice showed less ethanol-induced hypothermia but were impaired longer as compared to the younger mice. Blood ethanol levels at loss and regaining of the RR were lower for old mice than the younger mice. Body temperature for the youngest group was lower at each time of measurement as compared to the older groups. Age differences in body temperature prior to ethanol or saline injection were small and nonsignificant.
本实验研究了乙醇对C57BL/6NNIA雄性小鼠三个不同年龄组（8个月、18个月和28个月）体温的影响以及乙醇诱导的损伤情况。给小鼠腹腔注射3 g/kg乙醇或等量的生理盐水。测量体温、血液乙醇水平以及翻正反射（RR）消失和恢复的时间。在注射前以及注射后30分钟和120分钟也测量体温。与年轻小鼠相比，老年小鼠乙醇诱导的体温过低情况较轻，但恢复时间更长。老年小鼠RR消失和恢复时的血液乙醇水平低于年轻小鼠。与老年组相比，最年轻组在每次测量时的体温都更低。乙醇或生理盐水注射前体温的年龄差异较小且无统计学意义。
