Cambien F
Nouv Presse Med. 1982 Dec 4;11(49):3641-6.
The statistical correlation between obesity and essential hypertension is well established. The beneficial effect of weight reduction and the detrimental effect of weight gain on blood pressure have also been repeatedly demonstrated. The pathophysiological mechanisms underlying this correlation are still obscure, but various hypotheses, which sometimes favour different types of diet, have been put forward. Some studies suggest that energy restriction and salt restriction might have independent beneficial effects. Furthermore, the metabolic abnormalities associated with obesity are often improved by diet, whereas antihypertensive drugs may have deleterious effects. It would be of interest to know whether blood pressure response to diet is dependent upon the type of obesity. Controlled clinical trials comparing the effects of drugs and diet are highly desirable.
肥胖与原发性高血压之间的统计学关联已得到充分证实。体重减轻对血压的有益作用以及体重增加对血压的有害作用也已得到反复证实。这种关联背后的病理生理机制仍不清楚,但已提出了各种假说,这些假说有时支持不同类型的饮食。一些研究表明,能量限制和盐限制可能具有独立的有益作用。此外,与肥胖相关的代谢异常通常可通过饮食得到改善,而抗高血压药物可能具有有害作用。了解血压对饮食的反应是否取决于肥胖类型将是很有意思的。非常需要进行比较药物和饮食效果的对照临床试验。