Silverman J, Shellabarger C J, Holtzman S, Stone J P, Weisburger J H
J Natl Cancer Inst. 1980 Mar;64(3):631-4.
We studied the effect of dietary fat levels on the induction of mammary cancer by 350 rads total-body X-radiation given to noninbred albino Sprague-Dawley rats at 50 days of age. Compared to rats on a low-fat (LF) diet (5% lard), rats on a high-fat (HF) diet (20% lard) from 30 days of age had more tumors, with a higher multiplicity of carcinomas per rat. LF-fed groups exhibited a longer median tumor latency period thatn did HF-fed groups. A similar trend toward more tumors with an earlier time of death was seen in rats given single iv doses of 50 mg 1-methyl-1-nitrosourea/kg and fed an HF diet as compared to an LF diet.
我们研究了日粮脂肪水平对50日龄非近交白化斯普拉格-道利大鼠全身给予350拉德X射线诱发乳腺癌的影响。与低脂（LF）日粮（5%猪油）组大鼠相比，30日龄开始饲喂高脂（HF）日粮（20%猪油）的大鼠发生的肿瘤更多，每只大鼠的癌灶数量更多。LF日粮组大鼠的肿瘤潜伏期中位数比HF日粮组大鼠更长。与LF日粮组相比，单剂量静脉注射50 mg 1-甲基-1-亚硝基脲/kg并饲喂HF日粮的大鼠也出现了肿瘤更多且死亡时间更早的类似趋势。
