Sergeev S I, Kochetkova M K, Romanova O A
Vopr Onkol. 1978;24(10):61-5.
In comparative studies on the copper content and ceruloplasmin activity in blood of 212 patients with malignant melanoma, cancer and benign skin neoplasms, hypercupremia and an increased activity of the enzyme was revealed in 80% of patients with melanoma. Serum copper uptake in patients with non-pigmented melanoma was manifest to a greater extent. Some redistribution mechanisms are likely to underlie hypercupremia, that is especially indicated by the migration of copper from blood erythrocytes. Hypercupremia in patients with melanoma may be of a certain clinical interest as an accessory criterion for the differential diagnosis between malignant melanomas and benign skin neoplasms.
在对212例恶性黑色素瘤、癌症和良性皮肤肿瘤患者血液中的铜含量和铜蓝蛋白活性进行的比较研究中，80%的黑色素瘤患者出现高铜血症和酶活性增加。非色素性黑色素瘤患者的血清铜摄取更为明显。某些再分布机制可能是高铜血症的基础，这一点尤其体现在铜从血红细胞的迁移上。黑色素瘤患者的高铜血症作为恶性黑色素瘤与良性皮肤肿瘤鉴别诊断的辅助标准可能具有一定的临床意义。
