Scarpa R, Oriente P, Pucino A, Torella M, Vignone L, Gattozzi D
Boll Soc Ital Biol Sper. 1984 Mar 30;60(3):633-9.
Serum copper, iron and ceruloplasmin concentrations were determined in 45 subjects (20 males and 23 females, medium age 50.3, range 25-76) diagnosed as psoriatic arthritis patients, 63 patients (30 males and 33 females, medium age 32.4, range 10-78) with psoriasis, and in 60 blood donors (32 women and 28 men) as reference value group. Mean serum copper, iron and ceruloplasmin were significantly different (p less than .001) in psoriatic arthritis when compared with controls or subjects with psoriasis alone. The number of synovial joints affected was significantly correlated to changes in these serum parameters. Indeed serum copper, iron and ceruloplasmin were found significantly different from normals in the polyarticular subgroup, (p less than .001) while only copper and ceruloplasmin were different in mono-oligoarticular form (respectively p less than .001 and p less than .01). No significant changes were found in the spondiloarticular subgroup. In the polyarticular subgroup a direct correlation was found between another disease activity marker (e.g.ESR) and serum changes in iron, cerulosplasmin and copper (p less than .001).
对45名被诊断为银屑病关节炎患者（20名男性和23名女性，平均年龄50.3岁，范围25 - 76岁）、63名银屑病患者（30名男性和33名女性，平均年龄32.4岁，范围10 - 78岁）以及60名献血者（32名女性和28名男性）作为参考值组测定血清铜、铁和铜蓝蛋白浓度。与对照组或仅患银屑病的受试者相比，银屑病关节炎患者的血清铜、铁和铜蓝蛋白均值有显著差异（p <.001）。受影响的滑膜关节数量与这些血清参数的变化显著相关。确实，在多关节亚组中，血清铜、铁和铜蓝蛋白与正常水平有显著差异（p <.001），而在单寡关节型中只有铜和铜蓝蛋白有差异（分别为p <.001和p <.01）。在脊柱关节亚组中未发现显著变化。在多关节亚组中，发现另一种疾病活动标志物（如血沉）与铁、铜蓝蛋白和铜的血清变化之间存在直接相关性（p <.001）。
