Pohloudek-Fabini R, Martin E
Pharmazie. 1981 Oct;36(10):683-5.
Our studies have shown that the considerable losses of Thiomersal contained in low-density polyethylene bottles are not attributable, as suggested in the literature, to a sorption of this preserving agent. Intact Thiomersal is not sorbed by low-density polyethylene; on the contrary, the good permeability of this packing material to gas, especially oxygen, accelerates the degradation of Thiomersal. Furthermore, the ethylmercury resulting from this degradation is able to permeate through low-density polyethylene by which a displacement of the reaction equilibrium takes place in favour of the degradation products, and the degradation of Thiomersal is accelerated. The mechanism of the degradation of Thiomersal in the presence of oxygen was elucidated.
我们的研究表明，低密度聚乙烯瓶中硫柳汞的大量损失，并非如文献中所暗示的那样，是由于这种防腐剂的吸附作用。完整的硫柳汞不会被低密度聚乙烯吸附；相反，这种包装材料对气体，尤其是氧气的良好渗透性，加速了硫柳汞的降解。此外，这种降解产生的乙基汞能够透过低密度聚乙烯，从而使反应平衡向有利于降解产物的方向移动，加速了硫柳汞的降解。阐明了硫柳汞在氧气存在下的降解机制。
